Janine l. kwapis

Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. ...

Contextual Information Drives the Reconsolidation-Dependent Updating of Retrieved Fear Memories Timothy J Jarome1,2,4, Nicole C Ferrara1,4, Janine L Kwapis1,3 and Fred J Helmstetter*,1 1Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA Stored memories enter a temporary state of vulnerability following retrieval known as 'reconsolidation', a process that can ...Normal aging is accompanied by cognitive impairments, most notably disruptions in memory formation and updating, the ability to incorporate new information into existing memory. As lifespans increase...Bellfy, L.; Kwapis, J.L. Molecular Mechanisms of Reconsolidation-Dependent Memory Updating. Int. J. Mol. Sci. 2020 ... Janine Kwapis; Memory is not a stable record of experience, but instead is an ...AU - Kwapis, Janine L. AU - Trask, Sydney. AU - Pullins, Shane E. AU - Helmstetter, Fred J. N1 - Funding Information: This work was supported by National Institute of Health (NIH) grants MH112141 and AG053854 (FJH) and startup funds from the College of Agricultural and Life Sciences and the College of Science at Virginia Tech (TJJ).Janine Kwapis. Pennsylvania State University; Show all 11 authors Hide. ... activation, and that BDNF rescues theta-L TP and cocaine-associated memory deficits in. BAF53b transgenic mice.International Journal of Molecular Sciences Editorial Special Issue "Molecular Mechanisms of Memory Formation and Modification" Timothy J. Jarome 1,2,* and Janine L. Kwapis 3,4,* Citation: Jarome, T.J.; Kwapis, J.L. Special Issue "Molecular MechanismsA.J.L. designed study, analyzed data, interpreted results, and wrote the manuscript. The authors have no competing financial interest to disclose. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication.Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. …

Janine L Kwapis 1 , Timothy J Jarome 1 , Fred J Helmstetter 2 Affiliations 1 Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA. 2 Department of Psychology, University of PMID: 25512576 PMCID: 10. ...Int. J. Mol. Sci. 2021, 22, 4113 3 of 3 ity at M1 muscarinic receptors can override the effects of glutamate (mediated via GluN2A- and GluN2B-containing NMDARs), with an M1 agonist driving destabilization even in the presence of a GluN2B inhibitor that normally blocks destabilization. The M1 mAChR may therefore be a novel target capable of forcing an otherwise resistant memory to becomeLike reconsolidation, NMDA receptor activation is critical for memory extinction (Kwapis, Jarome, Lee, Gilmartin, & Helmstetter, 2014). Stimulation of β-adrenergic receptors by noradrenaline is known to potentiate fear memory extinction (Berlau & McGaugh, 2006; Mueller, Porter, & Quirk, 2008), while their inhibition by propranolol impairs it ...Janine L. Kwapis: Conceptualization, Writing - original draft, Writing - review & editing, Supervision, Funding acquisition. Declaration of Competing Interest. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Histone deacetylase 3 (HDAC3) is the most highly expressed Class I HDAC in the brain, and this specific HDAC is a powerful negative regulator of learning and memory processes (Kwapis et al., 2017, Malvaez et al., 2013, McQuown et al., 2011, Rogge et al., 2013).The broad goal of the proposed project is to understand how long-term memories are stored in the brain through the activity of protein kinase Mzeta (PKM?). Using rats, this project will determine the...This research was supported by the National Institutes of Mental Health (NIMH) Grant R01MH069558 to Fred J. Helmstetter and NIMH Grant F31MH090685 to Janine L. Kwapis. Appendix A . Supplementary materialThe circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian cycle, including memory processes, yet little is understood about how the clock interfaces with memory at a molecular level. The molecular circadian clock consists of four ...

Like reconsolidation, NMDA receptor activation is critical for memory extinction (Kwapis, Jarome, Lee, Gilmartin, & Helmstetter, 2014). Stimulation of β-adrenergic receptors by noradrenaline is known to potentiate fear memory extinction (Berlau & McGaugh, 2006; Mueller, Porter, & Quirk, 2008), while their inhibition by propranolol impairs it ...Jarome, Timothy J. ; Kwapis, Janine L. / Special issue "molecular mechanisms of memory formation and modification ...Janine Kwapis Page 2 • First Place Award for Oral Presentation, UCI ReMIND Emerging Scientists Symposium, UC Irvine 2015 • NIH T32 Institutional Training Grant Recipient, UCI MIND 2014-2016 • NIH F31 Predoctoral Ruth L. Kirschstein National Research Service Award (NRSA) - 3 year fellowship 2011-2013Lauren Bellfy Janine L. Kwapis. Biology. International Journal of Molecular Sciences. 2020; TLDR. Understanding the molecular mechanisms underlying reconsolidation-dependent memory updating is an important step toward leveraging this process in a therapeutic setting to modify maladaptive memories and to improve memory when it fails.

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The emphasis here is on the lines available as opposed to methods on how to develop transgenic mice, which has been discussed in detail previously (Doyle et al., 2012). Additionally, we will discuss other genetic tools available to neuroscientists, such as siRNAs, viral-mediated approaches, and variations of the CRISPR-Cas9 system.ARTICLE Aging mice show impaired memory updating in the novel OUL updating paradigm Janine L. Kwapis1,2, Yasaman Alaghband 1, Ashley A. Keiser 1, Tri N. Dong , Christina M. Michael , Diane Rhee , Guanhua Shu , Richard T. Dang1, Dina P. Matheos1 and Marcelo A. Wood1 Memories do not persist in a permanent, static state but instead must be dynamically modified in response to new information.Kwapis J. L., Jarome T. J., Schiff J. C., Helmstetter F. J. (2011). Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin. Janine L Kwapis; The circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian cycle ...

Janine Kwapis, assistant professor of biology at Penn State, appointed as the Paul Berg Early Career Professor in the Biological SciencesJanine L. Kwapis, Ph.D., Department of Biology, Penn State University ... it is unknown whether these biological processes share a common mechanism that is altered with age. Dr. Kwapis will present evidence that epigenetic regulation of the circadian gene Period1 (Per1) in the dorsal hippocampus is critical for memory formation and contributes ...Nicole C. Ferrara 1,2 Janine L. Kwapis 3 Sydney Trask 4,5* 1 Discipline of Physiology and Biophysics, Rosalind Franklin University, North Chicago, IL, United States 2 Center for Neurobiology of Stress Resilience and Psychiatric Disorders, Rosalind Franklin University, North Chicago, IL, United StatesJanine L Kwapis 1 , Timothy J Jarome 1 , Fred J Helmstetter 2 Affiliations 1 Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA.Kwapis JL, Jarome TJ, Gilmartin MR, Helmstetter FJ. Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory. Neurobiol Learn Mem. 2012; 98:148–153. doi: 10.1016/j.nlm.2012.05.003. [PMC free article] [Google Scholar]Janine L. Kwapis1, Sydney Trask 1, Shane E. Pullins1 & Fred J. Helmstetter1 Associations learned during Pavlovian fear conditioning are rapidly acquired and long lasting, providing an ideal model for studying long-term memory formation, storage, and retrieval. During retrieval, theseTimothy J Jarome, Craig T. Werner, Janine L. Kwapis, F. Helmstetter Biology, Psychology PloS one 2011 TLDR Evidence is provided that UPS-mediated protein degradation is a major regulator of synaptic plasticity necessary for the formation and stability of long ...Contributors: Janine L. Kwapis; Timothy J. Jarome; Marieke R. Gilmartin; Fred J. Helmstetter Show more detail. Source: Marieke Gilmartin via Crossref Metadata …

The circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian cycle, including memory processes, yet little is understood about how the clock interfaces with memory at a molecular level. The molecular circadian clock consists of four ...

Janine L. Kwapis; Yasaman Alaghband; Marcelo A. Wood; Article 15 Jun 2019. Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model.Brain derived neurotropic factor (BDNF) supports neuronal survival, growth, and differentiation and is involved in forms of hippocampus-dependent and independent learning, as well as hippocampus-dependent learning. Extinction learning comprises active inhibition of no-longer relevant learned information, in conjunction with a decreased response of a previously learned behavior. It is highly ...Janine L. Kwapis, Ph.D., Department of Biology, Penn State University ... it is unknown whether these biological processes share a common mechanism that is altered with age. Dr. Kwapis will present evidence that epigenetic regulation of the circadian gene Period1 (Per1) in the dorsal hippocampus is critical for memory formation and contributes ...Feb 17, 2023 · Nicole C. Ferrara 1,2 Janine L. Kwapis 3 Sydney Trask 4,5* 1 Discipline of Physiology and Biophysics, Rosalind Franklin University, North Chicago, IL, United States 2 Center for Neurobiology of Stress Resilience and Psychiatric Disorders, Rosalind Franklin University, North Chicago, IL, United States Janine L. Kwapis As seen in: JNeurosci. Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile Get in touch with Janine L. Contact Janine L., search articles and Tweets, monitor coverage, and track replies from ...AU - Kwapis, Janine L. AU - Trask, Sydney. AU - Pullins, Shane E. AU - Helmstetter, Fred J. N1 - Funding Information: This work was supported by National Institute of Health (NIH) grants MH112141 and AG053854 (FJH) and startup funds from the College of Agricultural and Life Sciences and the College of Science at Virginia Tech (TJJ).AU - Kwapis, Janine L. AU - Helmstetter, Fred J. PY - 2014/6. Y1 - 2014/6. N2 - Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKMζ) in maintaining established memory. PKMζ, an autonomously active isoform of PKC, is hypothesized to sustain those changes that occurred during ...learning and memory processes (Kwapis et al., 2017; Malvaez et al., 2013; McQuown et al., 2011; Rogge, Singh, Dang,&Wood, 2013). Our laboratory has shown that HDAC3 plays a critical role in object location and fear related memory formation (Kwapis et al., 2017; McQuown et al., 2011) using hippocampus and amygdala specific HDAC3 ma-nipulations.The editors depend heavily on outside reviewers in forming opinions about papers submitted to eNeuro and would like to formally thank the following individuals for their help during the past year.. Wickliffe C. Abraham. Rochelle Ackerley. Kirsten C. S. Adam

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Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA Corresponding author: fjh{at}uwm.edu Abstract The extinction of …First, we sought to compare learning-induced expression of Per1 between the young and aging RSC. Here, young (8-week-old) and aging (18-month-old) mice were either trained in OLM or left in their homecage at ZT5 and then sacrificed an hour later to examine Per1 expression via qPCR. Homecage control mice were handled and habituated to the context as part of the OLM protocol but remained in ...Adding trainee for Janine Kwapis Type a name and select match from the drop-down list. If no match exists, you will be prompted to add a new person to the tree. Name: School: Department: Relationship: Comments: Cancel Save. Adding mentor for Janine Kwapis Type a name and select match from the drop-down list. ...Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. WoodHistone deacetylase 3 (HDAC3) is the most highly expressed Class I HDAC in the brain, and this specific HDAC is a powerful negative regulator of learning and memory processes (Kwapis et al., 2017; Malvaez et al., 2013; McQuown et al., 2011; Rogge et al., 2013).The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons, a regeneration-incompetent central spinal cord …Finally, Bellfy and Kwapis review the evidence that the reconsolidation process may allow existing memories to update in response to new, relevant information . In their review, the authors outline the major behavioral paradigms used to study reconsolidation and describe the different molecular mechanisms across the brain that support this ...Jarome TJ, Kwapis JL, Werner CT, Parsons RG, Gafford GM, Helmstetter FJ (2012). The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation. Learn Mem 19: 300–306. [PMC free article] [Google Scholar] Jarome TJ, Werner CT, Kwapis JL, Helmstetter FJ … ….

Janine L. Kwapis: Conceptualization, Writing – original draft, Writing – review & editing, Supervision, Funding acquisition. Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Janine L Kwapis1,2, Timothy J Jarome1,3, Nicole C Ferrara1 and Fred J Helmstetter*,1 ... RSC as previously described (Kwapis et al, 2014a; Kwapis et al, 2015b; Kwapis et al, 2009). Rats were ...It is established that CAMKII is active within the perirhinal region between ∼20 and 100 min following learning and then returns to baseline, which is essential for the consolidation of long‐term object recognition memory. The aim was to investigate the role of calcium‐calmodulin‐dependent protein kinase (CAMK)II in object recognition memory.Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. by Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P Matheos, Marcelo A Wood.Christopher W. Butler, Ashley A. Keiser, Janine L. Kwapis, Nicole C. Berchtold, Vanessa L. Wall, Marcelo A. Wood, Carl W. CotmanThe circadian system influences many different biological processes, including memory performance. While the suprachiasmatic nucleus (SCN) functions as the brain's central pacemaker, satellite clocks have also been identified in other brain regions, such as the memory-relevant dorsal hippocampus. Although it is unclear how these satellite clocks contribute to brain function, one possibility ...Janine L Kwapis, 1, 2 Yasaman Alaghband, 1 Alberto J López, 1 André O White, 3 Rianne R Campbell, 1 Richard T Dang, 1 Diane Rhee, 1 Ashley V Tran, 1 Allison E Carl, 1 Dina P Matheos, 1 and Marcelo A Wood 1, 2, * Graham D. L. et al.. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat. Neurosci. 10, 1029-1037 (2007). [Google Scholar] Graham D. L. et al.. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol. Psychiatry 65, 696-701 (2009). Janine l. kwapis, Janine L. Kwapis, Timothy J. Jarome, and Fred J. Helmstetter Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined., Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. ..., Janine L. Kwapis, Ph.D. Assistant Professor Paul Berg Early Career Professor in the Biological Sciences Department of Biology, Pennsylvania State University Office: 516 Mueller Lab ½ Lab: 508 Mueller Lab University Park, PA 16802 Phone: 814-863-0859 Email: [email protected] Website: www.kwapislab.com CURRENT POSITION Pennsylvania State University , 13 Jul 2023 ... Molecular mechanisms of memory updating in young and old mice ▸ Janine Kwapis (Penn State). 61 views · 3 months ago UNIVERSITY OF CALIFORNIA ..., Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. …, Janine L Kwapis; The circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian cycle ..., Janine L. Kwapis. Department of Neurobiology and Behavior, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. UC Irvine Center for Addiction Neuroscience, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. Search for more papers by this author., The retrosplenial cortex is important for both the acquisition and retrieval of context fear, as blocking NMDA receptors within the RSC disrupts the retrieval of both recent and remote context fear memory (Corcoran et al., 2011) and blocking protein synthesis in the RSC or silencing the RSC during training impairs the acquisition of contextual ..., Research The Kwapis Lab studies the molecular and epigenetic mechanisms that underlie long-term memory formation, storage, and updating. We want to understand the mechanisms that underlie memory and identify how these mechanisms are dysregulated during aging, leading to age-related memory impairments., Janine L. Kwapis Scilit Preprints.org Google Scholar Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, PA 16802, USA, , Jun 1, 2023 · Additionally, the RSC has been demonstrated to play an important role in both the retrieval (Corcoran et al., 2011) and formation (Kwapis et al., 2015; Urban et al., 2021) of contextual fear memory. Both the anterior RSC (aRSC) and the posterior RSC (pRSC) have been implicated in spatial memory, although these subregions may each support ... , Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Communications in behavioral biology. Part A: [Original articles] on p. 110-116, The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning Janine L. Kwapis1, Timothy J. Jarome2, Jonathan L. Lee, Fred J. Helmstetter Department of Psychology, University of Wisconsin–Milwaukee, 2441 E. Hartford, How to say Janine L Kwapis in English? Pronunciation of Janine L Kwapis with and more for Janine L Kwapis., Finally, Bellfy and Kwapis review the evidence that the reconsolidation process may allow existing memories to update in response to new, relevant information . In their review, the authors outline the major behavioral paradigms used to study reconsolidation and describe the different molecular mechanisms across the brain that support this ..., The broad goal of the proposed project is to understand how long-term memories are stored in the brain through the activity of protein kinase Mzeta (PKM?). Using rats, this project will determine the..., Brandon L. Roberts; Ilia N. Karatsoreos; Research Open Access 06 Jun 2023 Scientific Reports. ... Janine L. Kwapis; Research 01 Jun 2023 Neuropsychopharmacology. P: 1-9. All Research & Reviews., Correspondence: Janine L. Kwapis ([email protected]) 2 Present address: Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University ..., Lauren Bellfy Janine L. Kwapis. Biology. International Journal of Molecular Sciences. 2020; TLDR. Understanding the molecular mechanisms underlying reconsolidation-dependent memory updating is an important step toward leveraging this process in a therapeutic setting to modify maladaptive memories and to improve memory when it fails., We finally asked whether HDAC3 serine 424 phosphorylation (ser424) that controls HDAC3 activity and histone acetylation (Kwapis et al, 2017) is able to regulate DRG outgrowth. We overexpressed phospho‐mimetic or phospho‐dead HDAC3 S424A or S424D mutant plasmids in cultured DRG cells, respectively., Previous work from our lab (Kwapis et al., 2011, Kwapis et al., 2014, Kwapis et al., 2015) has demonstrated that a 6-trial trace fear conditioning protocol with a variable intertrial interval (ITI) of 240 ± 20 s produces approximately the same level of freezing as 4 trials of delay fear conditioning with a shorter ITI of 110 ± 20 s., This work was supported by the National Institute on Drug Abuse (DA025922 to M.A.W. and DA041838 to A.J.L.), the National Institute of Mental Health (MH101491 to M.A.W. and G.L., and support to A.J.L.), the National Institute of Neurological Disorders and Stroke (NS085709 to G.L. and NS105217 to A.J.L.) and National Institute of General …, Janine L. Kwapis, Timothy J. Jarome, and Fred J. Helmstetter. ... (NIMH) grants R01MH069558 to F.J.H. and NIMH grant F31MH090685 to J.L.K. We thank Marieke R. Gilmartin and Jonathan L. Lee for technical assistance. Footnotes [Supplemental material is available for this article.], Janine L. Kwapis1, Sydney Trask 1, Shane E. Pullins1 & Fred J. Helmstetter1 Associations learned during Pavlovian fear conditioning are rapidly acquired and long lasting, providing an ideal model for studying long-term memory formation, storage, and retrieval. During retrieval, these, Kwapis, Janine L López, Alberto J et al. Publication Date 2017-11-01 DOI 10.1016/j.nlm.2017.09.001 Peer reviewed eScholarship.org Powered by the California Digital Library University of California. Distinct roles for the deacetylase domain of HDAC3 in the, Mar 1, 2020 · Clean the training objects and chambers with 10% ethanol using paper towels. Dry the objects with a clean paper towel (or allow to air dry) before placing them in the chamber. For OUL, we use 200-mL tall-form beakers filled with cement. The objects are presented upside down, all facing the same direction. , Timothy J Jarome, Craig T. Werner, Janine L. Kwapis, F. Helmstetter. Biology, Psychology. PloS one. 2011; TLDR. Evidence is provided that UPS-mediated protein degradation is a major regulator of synaptic plasticity necessary for the formation and stability of long-term memories at amygdala synapses during memory formation and retrieval., Janine L. Kwapis, Marcelo A. Wood. Biology; Research output: Contribution to journal › Review article › peer-review. 69 Citations (SciVal) Overview; Fingerprint; Abstract. Post-traumatic stress disorder (PTSD) and other anxiety disorders stemming from dysregulated fear memory are problematic and costly. Understanding the molecular ..., The Neuroscience section of the Current Protocols journal covers research methods involving molecular pathways, synaptic transmission, behavioral techniques & imaging., Jan 31, 2017 · Europe PMC is an archive of life sciences journal literature. , Sydney Trask 1 , Nicole C Ferrara 2 , Aaron M Jasnow 3 , Janine L Kwapis 4 Affiliations 1 Department of Psychological Sciences, Purdue University, West Lafayette, IN, 47907, …, Alzheimer's Disease affects 5.4 million Americans [1] and by 2030, approximately 13.8 million people 65 or older are projected to have the disease [2]. Even more individuals will experience normal age...